Juicy Turkey Tenderloin Slow Cooker

Turkey tenderloin in the slow cooker takes a naturally lean cut and keeps it ridiculously juicy, thanks to a buttery Cajun herb blend. It is perfect for easy weeknights, meal prep Sundays, or if you just want a flavorful main without turning on the oven—especially on busy days.

What Makes It Special

• Juicy results without brining or fuss
• Just minutes of prep then you walk away
• Crowd-pleasing flavor juicy enough for sandwiches or the holiday table
• Works with pantry spices you likely already have
• I made this for a Friendsgiving years ago and everyone asked for leftovers I have made it for hectic weeknights ever since because it is truly foolproof

What You’ll Need

• Turkey tenderloin: Choose plump pieces with even thickness for best results Look for fresh or well-sealed packs in the meat section
• Butter: This brings moisture and richness Skip margarine for this recipe use real butter
• Cajun seasoning: Select a mild blend or one low in sodium to prevent overseasoning
• Dried thyme: Adds earthiness and helps round out the flavors Look for green vibrant thyme not gray or dusty
• Dried parsley: Brings color and a light herbal note
• Garlic powder and onion powder: These give deep flavor and make the seasoning base extra savory Opt for fresh spices from your pantry not something that has lost its punch
• Minced garlic: The jarred kind is great for this as it melts right into the sauce
• Chicken broth: Use low sodium broth for more control over saltiness It should smell fresh not sour

Let’s Cook This Together

Mix the Seasoning:

Combine Cajun seasoning thyme parsley garlic powder onion powder and salt if using in a small bowl Use a fork or clean hands to be sure the blend is even and ready to spread easily

Add Everything to the Slow Cooker:

Set your turkey tenderloins in the bottom Drizzle the melted butter and chicken broth all around Spoon the minced garlic over both sides and sprinkle your entire seasoning mix across every surface Pat with clean hands so it clings

Slow Cook Until Perfect:

Cover with the lid and set your slow cooker to high for about two to three hours or on low for four to six hours Use a meat thermometer to check for 165 degrees in the thickest part The turkey should look pale golden and there will be a pocket of garlic butter bubbling at the sides

Rest Your Tenderloin:

Lift each piece onto a cutting board and loosely tent with foil Let it relax for at least five to ten minutes so juices settle

Finish and Serve:

Slice the turkey against the grain into thick medallions Spoon those juices and garlic butter from the cooker right over the top for ultimate richness

Good to Know

• High in lean protein
• Great for meal prep reheats beautifully and stays juicy
• Leftovers freeze and thaw easily
• I love the richness that real butter adds to this dish Every Thanksgiving my dad eyes the slow cooker until it is time to slice and it always disappears faster than anything else on the table

Keeping It Fresh

To store let the turkey cool fully Slice and pack in a container with extra sauce over the top Refrigerate for up to four days or freeze in slices tightly wrapped for up to two months Reheat gently in the microwave or covered in the oven with a splash of broth

Easy Ingredient Swaps

• No Cajun blend Try taco or Italian seasoning for a different kick
• Prefer herbaceous flavor Use rosemary and sage instead of Cajun and thyme
• Have no chicken broth Add water with an extra pinch of salt and a splash of lemon juice for brightness

How to Serve It Right

• Pile sliced turkey over mashed potatoes or creamy polenta Drizzle with all the butter sauce
• For a lighter meal add to leafy salads with roasted veggies
• Leftovers are incredible on sandwiches in wraps or even tossed into soups for extra protein

Behind the Dish

I first stumbled on this recipe hunting for a hands off Thanksgiving main My slow cooker saves the day whenever I need room in the oven or want a worry free meal The Cajun spices please everyone and you never get that dried out turkey feeling

Recipe FAQs

→ How can I keep turkey tenderloin moist in the slow cooker?

Cook with broth, use plenty of butter, and avoid overcooking. Letting the turkey rest before slicing also helps retain its juices.

→ Can I substitute Cajun seasoning with something else?

You can use Italian seasoning, poultry seasoning, or your favorite spice blend depending on your flavor preference.

→ How do I know when the turkey is done?

Turkey is cooked through when it reaches an internal temperature of at least 165℉ as measured by a food thermometer.

→ Is it necessary to sear the turkey before slow cooking?

Searing is optional for added flavor, but not required for this preparation. The slow cooker keeps the meat tender without searing.

→ How should leftovers be stored?

Cool any leftovers, then store in an airtight container in the refrigerator for up to 3-4 days. Reheat gently to preserve juiciness.

→ Can I add vegetables to the slow cooker?

Absolutely! Add carrots, potatoes, or onions for a complete and flavorful one-pot meal.